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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12910 | Sigma-1 receptor antagonist 1 | Sigma receptor | |
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie... | |||
T12911 | Sigma-1 receptor antagonist 2 | Sigma receptor | |
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively). | |||
T12912 | Sigma-1 receptor antagonist 3 | Sigma receptor , HER | |
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain. | |||
T16883 | Sigma-2 receptor antagonist 1 | Others | |
Sigma-2 receptor antagonist 1 is an antagonist of the sigma-2 (σ-2) receptor. | |||
T4596 | 4-IBP | Sigma receptor | |
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) . | |||
T9244 | σ1 Receptor antagonist-1 | Sigma receptor | |
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist. | |||
T7488 | BD1063 dhydrochloride | BD1063 | Sigma receptor |
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM). | |||
T78734 | Sigma-1 receptor antagonist 5 | Sigma receptor | |
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor... | |||
T5027 | Dimemorfan phosphate | 3,17-dimethylmorphinan | Sigma receptor |
Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive. | |||
T1180 | Blonanserin | AD-5423 | Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor |
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ... | |||
T15393 | Glycerol phenylbutyrate | HPN-100 | Sigma receptor |
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02). | |||
T7780 | Blarcamesine | AE-37,AVex-73 | AChR |
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. | |||
T1740 | BD-1047 dihydrobromide | BD1047.2HBr | Sigma receptor |
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia. | |||
T15034 | Roluperidone | CYR-101,MIN-101,MT-210 | Sigma receptor , 5-HT Receptor |
Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2). | |||
T8834 | EST64454 hydrochloride | EST64454 | Sigma receptor |
EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management. | |||
T5969 | Ditolylguanidine | DTG,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine | Sigma receptor |
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor). | |||
T1885 | Siramesine hydrochloride | Lu 28-179 hydrochloride | Ferroptosis , Sigma receptor , lysosomal autophagy |
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo. | |||
T4111 | Blarcamesine hydrochloride | Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride | Sigma receptor |
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). | |||
T3198L | PRE-084 hydrochloride | Sigma receptor | |
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). | |||
T1865 | S1RA | E-52862 | Sigma receptor |
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM). |